Resource,Source,Identifier Anti-Actin Antibody, clone C4,Sigma-Aldrich,RRID:AB_2223041 Goat Anti-GAPDH Polyclonal antibody, Unconjugated,Santa Cruz Biotechnology,RRID:AB_641107 Anti-GFP,Roche,RRID:AB_390913 Anti-HA High Affinity; Rat monoclonal antibody (clone 3F10),Roche,RRID:AB_390918 Monoclonal ANTI-FLAGĀ® M2 antibody produced in mouse,Sigma-Aldrich,RRID:AB_262044 RPS27A antibody,Abcam,RRID:AB_10863285 UBA52 Polyclonal Antibody,Thermo Fisher Scientific,RRID:AB_2541185 Ubiquitin Antibody, Clone FK2: Dylight 405,StressMarq Biosciences,RRID:AB_2820835 Ub Antibody (P4D1),Santa Cruz Biotechnology,RRID:AB_2762364 Anti-Ubiquitin (linkage-specific K27) antibody [EPR17034] ,Abcam,RRID:AB_2713902 Ub-K33 Polyclonal Antibody,Thermo Fisher Scientific,RRID:AB_2914195 Anti-Ubiquitin, Lys48-Specific, clone Apu2,Millipore,RRID:AB_11213655 Anti-Polyubiquitin (K63-linkage-specific) Monoclonal Antibody, Unconjugated, Clone HWA4C4,Enzo Life Sciences,RRID:AB_2052278 SUV39H1 (D11B6) Rabbit mAb,Cell Signaling Technology,RRID:AB_10829612 Anti-SUV39H2,LSBio (LifeSpan),RRID:AB_10914491 Rabbit anti-TRIP12 Antibody, Affinity Purified,Bethyl,RRID:AB_1264344 Anti-JMJD1B / JHDM2B Antibody, Unconjugated,Cell Signaling Technology,RRID:AB_915946 JMJD2A Antibody,Novus,RRID:AB_669535 Anti-Histone H3 (tri methyl K9) antibody [EPR16601] - ChIP Grade,Abcam,RRID:AB_2797591 KMT1E / SETDB1 antibody [5H6A12],Abcam,RRID:AB_10861045 anti-BRD4 (E2A7X) Rabbit Antibody,Cell Signaling Technology,RRID:AB_2687578 Rabbit Anti-Histone H3, phospho (Ser10) Mitosis marker Polyclonal antibody, Unconjugated,Millipore,RRID:AB_310177 Anti-53BP1, clone BP13,Millipore,RRID:AB_11212586 Anti-phospho-Histone H2A.X (Ser139) Antibody, clone JBW301,Millipore,RRID:AB_309864 HeLa,Cellosaurus,RRID:CVCL_0030 U2OS,Cellosaurus,RRID:CVCL_0042 DG-S2,Cellosaurus,RRID:CVCL_A9EU pFN18A-HaloTag-Biotin,Addgene,RRID:Addgene_206039 UCSF ChimeraX,https://www.cgl.ucsf.edu/chimerax/,RRID:SCR_015872 sigma-tau,http://www.sigma-tau.it/eng/,RRID:SCR_000488 python-bx,https://github.com/bxlab/bx-python,RRID:SCR_024202 MaxQuant,http://www.biochem.mpg.de/5111795/maxquant,RRID:SCR_014485 UniProtKB,http://www.uniprot.org/help/uniprotkb,RRID:SCR_004426 ENCODE,http://genome.ucsc.edu/ENCODE,RRID:SCR_006793 MatPlotLib,http://matplotlib.sourceforge.net,RRID:SCR_008624