Resource,Source,Identifier Rad51 (3C10),Santa Cruz Biotechnology,RRID:AB_630180 Actin Monoclonal Antibody (ACTN05 (C4)),Thermo Fisher Scientific,RRID:AB_11004139 Mouse Anti-PPAR beta Monoclonal Antibody, Unconjugated, Clone F-7,Santa Cruz Biotechnology,RRID:AB_1128605 IRDye 800CW Goat anti-Mouse IgG,LI-COR Biosciences,RRID:AB_621842 IRDye 680RD Donkey anti-Rabbit IgG,LI-COR Biosciences,RRID:AB_10954442 Mouse Anti-MRE11 Monoclonal Antibody, Unconjugated,Santa Cruz Biotechnology,RRID:AB_2145244 Exo1 (266),Santa Cruz Biotechnology,RRID:AB_783300 discontinued product,Bethyl,RRID:AB_2632119 Histone H3 Polyclonal Antibody,Thermo Fisher Scientific,RRID:AB_10985434 MSH2 Monoclonal Antibody (FE11),Thermo Fisher Scientific,RRID:AB_2533139 MSH3 Polyclonal Antibody,Thermo Fisher Scientific,RRID:AB_2899400 Mouse Anti-Human SMARCAD1 Polyclonal Antibody, Unconjugated,Abcam,RRID:AB_1142946 Anti-PARP1 antibody,Abcam,RRID:AB_2895023 PARG Polyclonal Antibody,Thermo Fisher Scientific,RRID:AB_2720265 Histone H3 Monoclonal Antibody (865R2),Thermo Fisher Scientific,RRID:AB_10375008 Anti-Lamin B1 antibody - Nuclear Envelope Marker,Abcam,RRID:AB_443298 Anti-β-Actin Antibody (C4),Santa Cruz Biotechnology,RRID:AB_626632 RPA 14 kDa subunit (E-2),Santa Cruz Biotechnology,RRID:AB_10649042 Rabbit Anti-RPA32 / RPA2 Monoclonal Antibody, Unconjugated, Clone EPR2877Y,Abcam,RRID:AB_1524336 RPA70 Monoclonal Antibody (11H4),Thermo Fisher Scientific,RRID:AB_2884060 ALDH2 Monoclonal Antibody (4G6A3),Thermo Fisher Scientific,RRID:AB_2538501 TDP1 Polyclonal Antibody,Thermo Fisher Scientific,RRID:AB_2812803 TTRAP antibody,Proteintech,RRID:AB_1607504 PLK1 Monoclonal Antibody (36-298),Thermo Fisher Scientific,RRID:AB_2533336 p53 (Pab 240),Santa Cruz Biotechnology,RRID:AB_628086 Phospho-TBK1/NAK (Ser172) (D52C2) XP Rabbit monoclonal Antibody,Cell Signaling Technology,RRID:AB_10693472 TBK1/NAK (D1B4) XP(tm) Rabbit mAb,Cell Signaling Technology,RRID:AB_2255663 CtIP Polyclonal Antibody,Thermo Fisher Scientific,RRID:AB_11153016 Rabbit anti-UBE2O Antibody, Affinity Purified,Bethyl,RRID:AB_1309799 Anti-phospho-Histone H2A.X (Ser139) Antibody, clone JBW301,Millipore,RRID:AB_309864 5-Methylcytosine (5-mC) (D3S2Z) Rabbit mAb,Cell Signaling Technology,RRID:AB_2798962 HUWE1 antibody,Proteintech,RRID:AB_2878579 WWP2 antibody,Proteintech,RRID:AB_10597536 CHFR antibody,Proteintech,RRID:AB_2080821 Phospho-p44/42 MAPK (Erk1) (Tyr204)/(Erk2) (Tyr187) (D1H6G) Mouse mAb,Cell Signaling Technology,RRID:AB_2797617 p44/42 MAPK (Erk1/2) (137F5) Rabbit mAb,Cell Signaling Technology,RRID:AB_390779 Anti-Poly ADP-ribose Antibody, clone 10H,Millipore,RRID:AB_2861394 BrdU,Santa Cruz Biotechnology,RRID:AB_2313786 DNMT3A (D23G1) XP(tm) Rabbit mAb,Cell Signaling Technology,RRID:AB_2277449 TET2 Antibody,Cell Signaling Technology,RRID:AB_2799277 Rabbit anti-Mouse IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor™ 594,Thermo Fisher Scientific,RRID:AB_2534109 Rat Anti-Rat IgG (H+L) Antibody, Alexa Fluor? 488 Conjugated,Thermo Fisher Scientific,RRID:AB_10561519 Goat anti-Mouse IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor™ 488,Thermo Fisher Scientific,RRID:AB_2534069 Goat anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor™ 647,Thermo Fisher Scientific,RRID:AB_2535813 Goat Anti-Rabbit IgG Antibody, HRP-conjugate,Sigma-Aldrich,RRID:AB_390191 Goat Anti-Mouse IgG Antibody, HRP conjugate,Sigma-Aldrich,RRID:AB_390192 BrdU (5-bromo-2-deoxyuridine),Cytiva,RRID:AB_2314032 Goat anti-Mouse IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor™ 568,Thermo Fisher Scientific,RRID:AB_2534072 Goat anti-Rabbit IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor™ 488,Thermo Fisher Scientific,RRID:AB_143165 32D,Cellosaurus,RRID:CVCL_0118 Unknown,Cellosaurus,RRID:CVCL_WG5 32D-Flt3-ITD,Cellosaurus,RRID:CVCL_WG50 HEL 92.1.7,Cellosaurus,RRID:CVCL_2481 SET-2,Cellosaurus,RRID:CVCL_2187 A-549,Cellosaurus,RRID:CVCL_0023 HCC15,Cellosaurus,RRID:CVCL_2057 HEK293T/17,Cellosaurus,RRID:CVCL_1926 pCMMP-MCS-IRES-mRFP,Addgene,RRID:Addgene_36972 pCL-Eco,Addgene,RRID:Addgene_12371 pMD2.G,Addgene,RRID:Addgene_12259 GraphPad Prism,http://www.graphpad.com/,RRID:SCR_002798 ImageJ,https://imagej.net/,RRID:SCR_003070 FlowJo,https://www.flowjo.com/solutions/flowjo,RRID:SCR_008520 sigma-tau,http://www.sigma-tau.it/eng/,RRID:SCR_000488 B6.Cg-Tg(Mx1-cre)1Cgn/J,Unknown,RRID:IMSR_JAX:003556