Resource,Source,Identifier SH-SY5Y,Cellosaurus,RRID:CVCL_0019 pEF1α-Cre-2A-Puro,Addgene,RRID:Addgene_207743 pSpCas9(BB)-2A-Puro-SMCR8,Addgene,RRID:Addgene_83440 2Flag-pDEST-N,Addgene,RRID:Addgene_118371 I-TASSER,http://zhanglab.ccmb.med.umich.edu/I-TASSER/,RRID:SCR_014627 PyMOL,http://www.pymol.org/,RRID:SCR_000305 sigma-tau,http://www.sigma-tau.it/eng/,RRID:SCR_000488 ImageJ,https://imagej.net/,RRID:SCR_003070 Proteome Discoverer,https://www.thermofisher.com/order/catalog/product/IQLAAEGABSFAKJMAUH,RRID:SCR_014477 Ingenuity Pathway Analysis,http://www.ingenuity.com/products/pathways_analysis.html,RRID:SCR_008653