Resource,Source,Identifier Anti-phospho-Histone H2A.X (Ser139) Antibody, clone JBW301,Millipore,RRID:AB_309864 Goat anti-Rabbit IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluorâ„¢ 488,Thermo Fisher Scientific,RRID:AB_143165 8-oxo-dG Antibody,R and D Systems,RRID:AB_1857195 Sorbitol Dehydrogenase Antibody (E-8),Santa Cruz Biotechnology,RRID:AB_3095045 Aldose Reductase (H-6),Santa Cruz Biotechnology,RRID:AB_10609906 Goat anti-Mouse IgG (H+L) Secondary Antibody, HRP,Thermo Fisher Scientific,RRID:AB_10960845 APNG (3D1),Santa Cruz Biotechnology,RRID:AB_1119016 Phospho-ATM (Ser1981) (10H11.E12) Mouse mAb,Cell Signaling Technology,RRID:AB_2062663 Rabbit Anti-ATM Monoclonal Antibody, Unconjugated, Clone D2E2,Cell Signaling Technology,RRID:AB_2062659 Beta-Tubulin Antibody,Cell Signaling Technology,RRID:AB_2210545 Glucose-6-Phosphate Dehydrogenase Antibody,Cell Signaling Technology,RRID:AB_10827744 Anti-Glucose Transporter Glut1 Antibody (A-4),Santa Cruz Biotechnology,RRID:AB_2891096 Mouse Anti-Glut3 Monoclonal Antibody, Unconjugated, Clone B-6,Santa Cruz Biotechnology,RRID:AB_1124974 Goat anti-Rabbit IgG (H+L) Poly-HRP Secondary Antibody, HRP,Thermo Fisher Scientific,RRID:AB_1965959 Mouse Anti-GPx-4 Monoclonal Antibody, Unconjugated,Santa Cruz Biotechnology,RRID:AB_2112427 HCNP (C-9),Santa Cruz Biotechnology,RRID:AB_10610225 Histone H3 Antibody,Cell Signaling Technology,RRID:AB_331563 Hexokinase I (C35C4) Rabbit mAb,Cell Signaling Technology,RRID:AB_2116996 Rabbit Anti-Hexokinase II Monoclonal Antibody, Unconjugated, Clone C64G5,Cell Signaling Technology,RRID:AB_2232946 Keap1 (G-2),Santa Cruz Biotechnology,RRID:AB_10844829 Nuclear factor (erythroid-derived 2)-like 2,Santa Cruz Biotechnology,RRID:AB_10917561 Mouse Anti-NTH1 Monoclonal Antibody, Unconjugated,Santa Cruz Biotechnology,RRID:AB_2154558 Muscle Phosphofructokinase/PFKM/PFK-1 Antibody (JU53-31),Novus,RRID:AB_3095046 Anti-PFKFB1 antibody,Abcam,RRID:AB_3095047 PFKFB3-Specific antibody,Proteintech,RRID:AB_2162854 anti-PFKFB4 antibody,Abcam,RRID:AB_2722775 Rabbit Anti-PKM2 XP Monoclonal Antibody, Unconjugated, Clone D78A4,Cell Signaling Technology,RRID:AB_1904096 Rad51 (D4B10) Rabbit mAb,Cell Signaling Technology,RRID:AB_2721109 Rabbit Anti-PKM2, phospho (Tyr105) Antibody, Unconjugated,Cell Signaling Technology,RRID:AB_1950369 UDG (k1C12),Santa Cruz Biotechnology,RRID:AB_1131097 uracil-DNA glycosylase Antibody,Novus,RRID:AB_10012175 XRCC3 Antibody,Novus,RRID:AB_922791 HCC827,Cellosaurus,RRID:CVCL_2063 PC9-BrM3,Cellosaurus,RRID:CVCL_XA19 ImageJ,https://imagej.net/,RRID:SCR_003070 CellProfiler Image Analysis Software,http://cellprofiler.org,RRID:SCR_007358 sigma-tau,http://www.sigma-tau.it/eng/,RRID:SCR_000488 Gene Expression Omnibus (GEO),https://www.ncbi.nlm.nih.gov/geo/,RRID:SCR_005012 Ingenuity Pathway Analysis,http://www.ingenuity.com/products/pathways_analysis.html,RRID:SCR_008653 GraphPad Prism,http://www.graphpad.com/,RRID:SCR_002798 Cytoscape,http://cytoscape.org,RRID:SCR_003032