Resource,Source,Identifier Oct3/4 Antibody (C-10),Santa Cruz Biotechnology,RRID:AB_628051 Sox-2 (E-4),Santa Cruz Biotechnology,RRID:AB_10842165 Tri-Methyl-Histone H3 (Lys9) (D4W1U) Rabbit mAb,Cell Signaling Technology,RRID:AB_2798355 Rabbit Anti-Histone H3, trimethyl (Lys9) ChIP Grade Polyclonal Antibody, Unconjugated,Abcam,RRID:AB_306848 Anti-DYKDDDK Antibody, Unconjugated,Cell Signaling Technology,RRID:AB_2217020 Rabbit Anti-Histone H3, Trimethyl (Lys27) Monoclonal Antibody, Unconjugated, Clone C36B11,Cell Signaling Technology,RRID:AB_2616029 5-Methylcytosine (5-mC) antibody,Active Motif,RRID:AB_2687950 Goat Anti-Human Gata-6 Polyclonal antibody, Unconjugated,R and D Systems,RRID:AB_2108901 Phospho-p53 (Ser15) (16G8) Mouse mAb,Cell Signaling Technology,RRID:AB_331741 p53 (1C12) Mouse mAb,Cell Signaling Technology,RRID:AB_331743 p-Histone H3 (C-2),Santa Cruz Biotechnology,RRID:AB_11150094 Rabbit Anti-Histone H2A.X, phospho (Ser139) Monoclonal Antibody, Unconjugated, Clone EP854(2)Y,Abcam,RRID:AB_1640564 Anti-C3orf63 antibody produced in rabbit,Sigma-Aldrich,RRID:AB_1852382 MPP8 antibody,Proteintech,RRID:AB_2266644 Anti-β Tubulin Antibody (D-10),Santa Cruz Biotechnology,RRID:AB_2288090 Phospho-Smad2 (Ser465/467)/Smad3 (Ser423/425) (D27F4) Rabbit mAb,Cell Signaling Technology,RRID:AB_2631089 Recombinant Anti-LINE-1 ORF1p antibody [EPR21844-108],Abcam,RRID:AB_2921327 Monoclonal ANTI-FLAG® M2 antibody,Sigma-Aldrich,RRID:AB_259529 BrdU,BD Biosciences,RRID:AB_10015219 Rat Anti-BrdU Monoclonal Antibody, Unconjugated, Clone BU1 / 75 (ICR1),Abcam,RRID:AB_305426 Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor™ 647,Thermo Fisher Scientific,RRID:AB_2536183 Donkey Anti-Mouse IgG (H+L) Antibody, Alexa Fluor 488 Conjugated,Molecular Probes,RRID:AB_141607 Donkey anti-Goat IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor™ 555,Thermo Fisher Scientific,RRID:AB_2535853 sigma-tau,http://www.sigma-tau.it/eng/,RRID:SCR_000488 FlowJo,https://www.flowjo.com/solutions/flowjo,RRID:SCR_008520 PRISM,http://bejerano.stanford.edu/prism/public/html/,RRID:SCR_005375 GraphPad,http://graphpad.com/,RRID:SCR_000306 ChIP-seq,https://gitlab.sib.swiss/EPD/chipseq,RRID:SCR_001237 ggplot2,https://cran.r-project.org/web/packages/ggplot2/index.html,RRID:SCR_014601 RColorBrewer,https://cran.r-project.org/web/packages/RColorBrewer/index.html,RRID:SCR_016697 Benchling,https://benchling.com,RRID:SCR_013955 RefSeq,http://www.ncbi.nlm.nih.gov/RefSeq/,RRID:SCR_003496 SAMTOOLS,http://htslib.org/,RRID:SCR_002105 DESeq,http://bioconductor.org/packages/release/bioc/html/DESeq.html,RRID:SCR_000154 featureCounts,http://bioinf.wehi.edu.au/featureCounts/,RRID:SCR_012919 Picard,http://broadinstitute.github.io/picard/,RRID:SCR_006525 BEDTools,https://github.com/arq5x/bedtools2,RRID:SCR_006646