Resource,Source,Identifier Mono- and polyubiquitinylated conjugates recombinant monoclonal antibody (UBCJ2),Enzo Life Sciences,RRID:AB_2935893 STING Monoclonal Antibody (OTI4H1),Thermo Fisher Scientific,RRID:AB_2725437 STING/TMEM173 Antibody,Novus,RRID:AB_2868483 Anti-Ubiquitin K48-Specific Antibody, clone Apu2 ZooMAb® Rabbit Monoclonal,Sigma-Aldrich,RRID:AB_2928997 Rabbit Anti-Ubiquitin, Lys63-Specific Monoclonal antibody, Unconjugated, Clone apu3,Millipore,RRID:AB_1587580 Anti-Linear Ubiquitin Antibody, clone 1E3 ZooMAb® Rabbit Monoclonal,Sigma-Aldrich,RRID:AB_2938573 Rabbit Anti-GAPDH Antibody, Unconjugated,Sigma-Aldrich,RRID:AB_796208 RBCK1 antibody,Proteintech,RRID:AB_2880493 SHARPIN antibody,Proteintech,RRID:AB_2187734 Anti-LC3B antibody produced in rabbit,Sigma-Aldrich,RRID:AB_796155 STING (D2P2F),Cell Signaling Technology,RRID:AB_2732796 TNIP1 antibody,Proteintech,RRID:AB_2207757 NF-kappaB p65 (D14E12) XP Rabbit mAb,Cell Signaling Technology,RRID:AB_10859369 Phospho-NF-κB p65 (Ser536) (93H1) Rabbit mAb,Cell Signaling Technology,RRID:AB_331284 TBK1/NAK Antibody,Cell Signaling Technology,RRID:AB_2199749 Phospho-TBK1/NAK (Ser172) (D52C2) XP Rabbit monoclonal Antibody,Cell Signaling Technology,RRID:AB_10693472 IRF-3 (D83B9) Rabbit mAb,Cell Signaling Technology,RRID:AB_1904036 IRF3 (phospho S386) antibody [EPR2346],Abcam,RRID:AB_1523836 Anti-Actin Antibody, clone C4,Sigma-Aldrich,RRID:AB_2223041 Goat anti-Rabbit IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor™ 647,Thermo Fisher Scientific,RRID:AB_2535812 Goat anti-Mouse IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor™ 647,Thermo Fisher Scientific,RRID:AB_2535804 Goat anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor™ 546,Thermo Fisher Scientific,RRID:AB_2534093 Goat anti-Mouse IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor™ 546,Thermo Fisher Scientific,RRID:AB_2534071 Amersham ECL Rabbit IgG, HRP-linked F(ab')₂ fragment (from donkey),Cytiva,RRID:AB_772191 HIRcB,Cellosaurus,RRID:CVCL_0300 HeLa,Cellosaurus,RRID:CVCL_0030 HEK293T,Cellosaurus,RRID:CVCL_0063 pSpCas9(BB)-2A-Puro (PX459) V2.0,Addgene,RRID:Addgene_62988 pLKO.1 puro,Addgene,RRID:Addgene_8453 IFN-Beta_pGL3,Addgene,RRID:Addgene_102597 pcDNA5FRT/TO-HOIP-Strep-HA,Addgene,RRID:Addgene_113494 pLKO.1C,Addgene,RRID:Addgene_139470 GraphPad Prism,http://www.graphpad.com/,RRID:SCR_002798 MATLAB,http://www.mathworks.com/products/matlab/,RRID:SCR_001622 PRISM,http://bejerano.stanford.edu/prism/public/html/,RRID:SCR_005375