Resource,Source,Identifier DNA PKcs antibody,Abcam,RRID:AB_1209452 Ku80/XRCC5 Antibody - BSA Free,Novus,RRID:AB_2218753 Mre11 Antibody,Novus,RRID:AB_10077796 Rad50 Antibody,Novus,RRID:AB_2894913 NBS1 Antibody,Novus,RRID:AB_10078050 PARP Antibody,Novus,RRID:AB_3261341 RPA2 mouse monoclonal antibody, clone 1H10,OriGene,RRID:AB_11126590 RPA2 mouse monoclonal antibody, clone 7C12,OriGene,RRID:AB_11125493 Rabbit Anti-RPA32 / RPA2 Monoclonal Antibody, Unconjugated, Clone EPR2877Y,Abcam,RRID:AB_1524336 CIRBP antibody,Abcam,RRID:AB_10863015 Mouse Anti-p53 Monoclonal Antibody, Unconjugated, Clone PAb 240,Abcam,RRID:AB_303198 p53 antibody,Abcam,RRID:AB_11155283 Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488),Abcam,RRID:AB_2630356 StarBright™ Blue 520 Goat Anti-Mouse IgG,Bio-Rad,RRID:AB_2934034 NOT AN ANTIBODY Streptavidin - HRP,Thermo Fisher Scientific,RRID:AB_2619743 HEK293T,Cellosaurus,RRID:CVCL_0063 pUC19-Cv3,Addgene,RRID:Addgene_99351 pGEM5Z(+)-EGFP,Addgene,RRID:Addgene_65206 p189,Addgene,RRID:Addgene_65207 EBFP2-N1,Addgene,RRID:Addgene_54595 ImageJ,https://imagej.net/,RRID:SCR_003070 Charles River Laboratories,http://www.criver.com/,RRID:SCR_003792 GraphPad Prism,http://www.graphpad.com/,RRID:SCR_002798 WU-BLAST,http://www.ebi.ac.uk/Tools/sss/wublast/,RRID:SCR_011824 sigma-tau,http://www.sigma-tau.it/eng/,RRID:SCR_000488 fastp,https://github.com/OpenGene/fastp,RRID:SCR_016962 DESeq,http://bioconductor.org/packages/release/bioc/html/DESeq.html,RRID:SCR_000154 python-bx,https://github.com/bxlab/bx-python,RRID:SCR_024202 Whole Genome Shotgun (WGS) Project,https://www.ncbi.nlm.nih.gov/genbank/wgs/,RRID:SCR_016637 University of Rochester Light Microscopy Resource Core Facility,http://www.urmc.rochester.edu/confocal-conventional-microscopy/index.cfm,RRID:SCR_023177