Resource,Source,Identifier Rabbit anti-ATR Antibody, Affinity Purified,Bethyl,RRID:AB_2063318 Monoclonal Anti-β-Actin antibody produced in mouse,Sigma-Aldrich,RRID:AB_476697 BRCA1 (I-20),Santa Cruz Biotechnology,RRID:AB_630945 Chk1 (G-4),Santa Cruz Biotechnology,RRID:AB_627257 FANCD2 Antibody - BSA Free,Novus,RRID:AB_10002867 NECAB2 Monoclonal Antibody (CL0524),Thermo Fisher Scientific,RRID:AB_2637224 Rabbit Anti-Histone H3, monomethyl (Lys4) ChIP Grade Polyclonal Antibody, Unconjugated,Abcam,RRID:AB_306847 Anti-Histone H3 (tri methyl K4) antibody - ChIP Grade,Abcam,RRID:AB_306649 Rabbit Anti-gamma H2A.X, phospho (Ser139) Polyclonal Antibody, Unconjugated,Abcam,RRID:AB_297813 Human IgG antibody,Abcam,RRID:AB_303052 Rabbit (DA1E) mAb IgG XP Isotype Control,Cell Signaling Technology,RRID:AB_1550038 Anti-NanoLuc® Monoclonal Antibody,Promega,RRID:AB_3095534 Phospho-CHK1 (Ser345) Monoclonal Antibody (S.48.4),Thermo Fisher Scientific,RRID:AB_10979221 Rabbit anti-PHF6 Antibody, Affinity Purified,Bethyl,RRID:AB_961079 Anti-RPA32/RPA2 (phospho S33) antibody,Abcam,RRID:AB_2818947 RPA32/RPA2 antibody [9H8],Abcam,RRID:AB_302873 Anti-Mouse Detection Module,protein simple,RRID:AB_3095298 Anti-Rabbit Detection Module,protein simple,RRID:AB_3095297 VeriBlot for IP Detection Reagent (HRP),Abcam,RRID:AB_2892718 Anti-mouse IgG for IP (HRP),Abcam,RRID:AB_2895114 Vinculin (E1E9V) XP®,Cell Signaling Technology,RRID:AB_2728768 SK-N-BE(2)-C,Cellosaurus,RRID:CVCL_0529 SH-SY5Y,Cellosaurus,RRID:CVCL_0019 HCT 116,Cellosaurus,RRID:CVCL_0291 HEK293T,Cellosaurus,RRID:CVCL_0063 MaxQuant,http://www.biochem.mpg.de/5111795/maxquant,RRID:SCR_014485 ImageJ,https://imagej.net/,RRID:SCR_003070 RSEM,http://deweylab.biostat.wisc.edu/rsem/,RRID:SCR_013027 LIMMA,http://bioinf.wehi.edu.au/limma/,RRID:SCR_010943 Picard,http://broadinstitute.github.io/picard/,RRID:SCR_006525