BIORXIVbioRxivbioRxivCold Spring Harbor Laboratory10.64898/2026.03.03.7093601Regular Articlenew resultscancer biologyZNF423 depletion induces the integrated stress response and represents a potential vulnerability in NF1-associated MPNSTST88-14CellosaurusRRID:CVCL_8916Experimental Models: Cell LinesHEK293TCellosaurusRRID:CVCL_0063Experimental Models: Cell LinespLKO-shDAddgeneRRID:Addgene_21964Plasmidsscramble shRNAAddgeneRRID:Addgene_1864PlasmidspsPAX2AddgeneRRID:Addgene_12260PlasmidspMD2.GAddgeneRRID:Addgene_12259PlasmidsFlowJohttps://www.flowjo.com/solutions/flowjoRRID:SCR_008520Software and AlgorithmsImageJhttps://imagej.net/RRID:SCR_003070Software and AlgorithmsDESeqhttp://bioconductor.org/packages/release/bioc/html/DESeq.htmlRRID:SCR_000154Software and Algorithmspython-bxhttps://github.com/bxlab/bx-pythonRRID:SCR_024202Software and AlgorithmsMATLABhttp://www.mathworks.com/products/matlab/RRID:SCR_001622Software and AlgorithmsedgeRhttp://bioconductor.org/packages/edgeR/RRID:SCR_012802Software and AlgorithmsGraphPad Prismhttp://www.graphpad.com/RRID:SCR_002798Software and Algorithms